Towards a systematic framework for the synthesis of operable process intensification systems

In this work we present an integrated framework to derive intensified designs with guaranteed safety and operability performance. A step-by-step procedure is described featuring: (i) superstructure-based process synthesis using Generalized Modular Representation Framework, (ii) development of advanced multi-parametric control strategies following the PAROC framework and software platform, and (iii) inherent safety analysis at early design stage utilizing quantitative risk assessment. Two case studies with increasing intensification complexity, namely heat exchanger network synthesis and reactive distillation column design, are investigated to demonstrate the capabilities of the proposed framework. Application to reactive distillation systems. 29th European Symposium on Computer-Aided Process Engineering (ESCAPE-29); 2019; Accepted manuscript.